Burgess Lab Cytokinesis Resources

Abcission Proteins and Their Homologs ^(*)

In the table below you can find the abcission proteins and their homologs. Each protein of the different model organism links to its gene in the NCBI homepage.

Protein H. sapiens M. musculus S. purpuratus D. melanogaster C. celegans S. pombe S. cerevisiae

Spectrin SPTBN1   Spnb2   LOC590340 (Similar to beta spectrin)   beta-Spec   unc-70   ain1   SAC6
Dynamin II DNM2   Dnm2   LOC755951 (Similar to dynamin)   shi   dyn-1   dnm1 nr   Dnm1p nr
MKLP1 KIF23   Kif23   MKLP1/KRP110   pav   zen-4   klp5 nr   KIP1 nr
Kinesin II KIF5B   Kif5b   KRP -85/95 (Kinesin II)   Khc   unc-116   klp3   KIP1
Clathrin CLTC   Cltc   LOC759579 (Similar to clathrin-heavy chain)   Chc   chc-1   Chc1p   chc1(Predicted)
AP-2 AP2A2   Ap2a2   LOC592072 (Similar to AP-2)   alpha-Adaptin   alpha-adaptin   apl3   APL3
Dynamin DNM1L   Dnm1l   LOC577217   Drp1   drp-1   dnm1 nr   Dnm1p nr
ARF1 ARF1   Arf1   LOC586151(Similar to ARF1)   Arf79F   ARF   arf1   ARF1
Caveolin 3 CAV3   Cav3   LOC577275 (Similar to Caveolin 3)   na na na na
Syntaxin 1A STX1A   Stx1a   LOC373476 syntaxin   Syx1A   Syntaxin   sso1   SSO2
Syntaxin 5 STX5   Stx5   LOC579153 (Similar to Syntaxin 5A)   Syx5   syn-3   sed5(Predicted)   Sed5p
betaCOP COPB1   Copb1   LOC582249 (Similar to beta COP)   betaCop   Y25C1A.5   sec26   SEC26
Arfophilin/Fib3-Rab11 RAB11A   Rab11a   rab11 - Predicted   Rab11   rab-11.1   ypt3   YPT31

na:apparentaly absent in genome; nr:related molecules known, but no known function in cytokinesis

(*) We recognize that many of the proteins listed in this category may also play a role in other aspects of cytokinesis.

Other gene products associated to the completion of cytokinesis are available through the Gene Ontology website. Click on the link below to view more genes related to abcission from the Gene Ontology website:

http://amigo.geneontology.org/cgi-bin/amigo/term-assoc.cgi?term=GO:0007109