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Ring Component Proteins and Their Homologs (*)

In the table below you can find the ring component proteins and their homologs. Each protein of the different model organism links to its gene in the NCBI homepage.

Protein H. sapiens M. musculus S. purpuratus D. melanogaster C. elegans S. pombe S. cerevisiae
Rho GEFECT2  Ect2  ECT2  pbl  ect-2  Gef1  Rom1p  Rom2p  
Rho KinaseROCK1  Rock1  ROCK1  DROK  let-502  nana
RhoARhoA  RhoA  RhoA  Rho1  rho-1  Rho4 (hypothetical protein)  Rho1p  
ActinACTB  Actb  Actin  Act57B  actin  act1  Act1p  
ADF/CofilinCFL2  Cfl2  ADF/Cofilin (Predicted-XP_001189287)  tsr  unc-78  Cof1 (nr)  Cof1 (nr)  
AnillinANLN  Anln  LOC590990  Ani  ani-1  Mid1p  Mid2p  na
CYK-4RACGAP1  RAcgap1  naRAcGAP50C  cyk-4  nana
ForminFMN1  Fmn1  Formin (Predicted-XP_001185590)  dia  CYK-1  cdc12  Bni1p  Bnr1p  
KIF4KIF4A  Kif4  Similar to KIF4  KLP3A  klp-19  nana
MKLP1KIF23  Kif23  MKLP1/KRP110  pav  zen-4  nana
MKLP2/rab kinesin 6MKLP2  Rab6kifl  LOC579091  CG12298-PA (nr)  nanana
Myosin essential light chainMYL6B  Myl6b  Myosin light chain kinase (Predicted-LOC584840)  Mlc-c  mlc-3  cdc4  MLC1  
Myosin II heavy chainMYH2  Myh2  Similar to Myosin-2 heavy chain  Zipper  myo-3  myo2  Myo1p  
Myosin phosphataseMYPT1  Mypt1  LOC591869  DMYPT  mel-11  nana
Myosin regulatory light chainMRLC2  Mylc2b  Myosin regulatory light chain 2 (Predicted-XP_001177804)  sqh  mlc-4  Rlc1p  Mlc2p  
PRC-1PRC-1  Prc1  Prc1-prov  feo  SPD-1  SPAPB1A10.09 (nr)  Ase1p (nr)  
ProfilinPFN1  Pfn1  Profilin (NP_999760)  chic  PFN-1  cdc3  Pfy1p  
Septin 2SEPT2  Sept2  LOC583094 (hypothetical protein)  Septin-1  unc-59  spn1 (hypothetical protein)  Cdc3p  
Septin 9SEPT9  Sept9  LOC590420  pnut  unc-61  spn2 (hypothetical protein)  Cdc10p  

na:apparentaly absent in genome; nr:related molecules known, but no known function in cytokinesis

(*) We recognize that many of the proteins listed in this category may also play a role in other aspects of cytokinesis.


Other gene products associated to the contractile ring are available through the Gene Ontology website. Click on the link below to view more contractile ring genes from the Gene Ontology website:

http://amigo.geneontology.org/cgi-bin/amigo/term-assoc.cgi?term=GO:0005826

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