Burgess Lab Cytokinesis Resources

Signaling Proteins and Their Homologs ^(*)

In the table below you can find the RhoA pathway signaling proteins and their homologs. Each protein of the different model organism links to its gene in the NCBI homepage.

Protein H. sapiens M. musculus S. purpuratus D. melanogaster C. elegans S. pombe S. cerevisiae

Bud proteins na na na na na na/nr Axl1p  Axl2p  Bud3p
Bud4p  Bud8p  Bud9p
Rsr1p/Bud1p  Bud2p  Bud5p
Cdc42 GTPase module Cdc42 (nr)   Cdc42   LOC584477   Cdc42 (nr)   Cdc-42 (nr)   Cdc42 (nr; cell morphology)   Cdc42p  Cdc24p
Citron kinase CIT   Cit   CIT   sti   F59A6.5/W02B8.2   na na
Rho GEF ECT2   Ect2   ECT2   pbl   ect-2   Gef1   Rom1p  Rom2p
Rho Kinase ROCK1   Rock1   ROCK1   DROK   let-502   na na
RhoA RhoA   RhoA   RhoA   Rho1   rho-1   Rho4 (hypothetical protein)   Rho1p
Let-99 na na na na let-99   na na
G protein GNAO1   Gnao1   LOC414054   goa-1   G-oalpha47A   GPA1   gpa1

na:apparentaly absent in genome; nr:related molecules known, but no known function in cytokinesis

(*) We recognize that many of the proteins listed in this category may also play a role in other aspects of cytokinesis.