Under NSF DBI-0543506, we are now actively pursuing aspects of RNA secondary and tertiary structure prediction -- kinetic traps, space of k-point mutants, Boltzmann partition function computations by efficient algorithms. Tools we have developed and continue to develop will play a role in the design of RNA sequences optimized to have certain folding properties -- designer RNA. Under NSF DMS-0817971, we are analyzing cross hybridization in gene expression arrays.
Peter Clote has received a Digiteo Foundation Chair of Excellence to collaborate with computer science faculty at Ecole Polytechnique and l'Universite Paris-Sud (Orsay) on computational work concerning SELEX (in vitro selection), RNA design and structure. Digiteo Funding supports research from June 1, 2008 - May 31, 2012.