August 2015: McCarthy KR et al. (2015) Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface. PLoS Pathogens. DOI: 10.1371/journal.ppat.1005085
March 2015: Graduate students meet the public at the Museum of Science Health Fair!
On March 20-21, 2015, the Museum of Science held its first ever Health Fair, featuring local scientists studying microbes of all kinds. The goal of the fair was for local students and other museum visitors to meet real scientists and get a sense of the vast, invisible world of microbes. All of the graduate students in the lab participated, and worked hard to present what the lab does in an easy-to-digest format for museum visitors of all education levels. Here’s some of the information they presented:
Very Interesting Reading!!! De-discovering pathogens:Viral contamination strikes again!
10:00-12:00 Welkin Office Hours
12:00-2:00 Lab Meeting/Journal Club
2:00-2:30 Laura & Jen
9:00-10:15 Welkin Teaching
9:00-10:15 Welkin Teaching
No lab meeting on Jan 21…campus holiday
Lab Meeting will be moving to Room 552 at Noon!!!
Lab meeting on Jan 28 will be Ben with no Journal Club
Picture and Bios due for Website by Jan 28
Lab Jobs Changing on Jan 28
IMPORTANT: MANDATORY LAB SAFETY MEETING MONDAY FEB 4 at noon Room 552
“Two viruses and an elephant walk into a bar…”get the rest of the story by reading Welkin’s latest post on Small Things Considered
Convergent Evolution of Argonaute-2 Slicer Antagonism
in Two Distinct Insect RNA Viruses
Andrea presented a very interesting paper from PLoS Pathogens by van Mierlo et al, on RNAi inhibition of RNA viruses in insects, and specifically about proteins in two viruses that have apparently evolved to counteract RNAi. The paper combines genomics, molecular biology, and even some Drosophila genetics to make its point.
The paper citation is PLoS Pathog 8(8): e1002872. doi:10.1371/journal.ppat.1002872 and can be found here.
NEWS: Johnson Lab Page To Go Live Any Day Now
Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses.
Cell. 2012 Aug 17;150(4):831-41. doi: 10.1016/j.cell.2012.05.049.
Jamie presented a recent paper by our friend and colleague Nels Elde, based on work he did as a postdoc in Harmit Malik’s lab. Nels now has his own lab at the University of Utah. In this study, Nels and Harmit use deep-sequencing to take a close look at how poxvirus genomes evolve in response to selective pressure, revealing a unique mechanism they refer to as “gene accordions”. John Roth also published a nice commentary on the work.