From The MarthLab
[edit] Description
Many new massively parallel short-read sequencing technologies (e.g., 454, Illumina/Solexa, AB’s SoLID) are being used widely and widely for polymorphism discovery for medical re-sequencing projects. These new technologies are significantly different from the traditional Sanger sequencing, so it is essential to develop new methodologies and computational tools specifically designed for them. Collaborating with the Genome sequencing center at Washington University at St. Louis, Illumina/Solexa, and AB, we are developing new SNP discovery methods and tools for these new technologies. Currently, we have extended the capability of polyBayes program for SNP discovery on 454 and Illumina sequences. We have built an accurate base caller PyroBayes for 454 sequences. In addition, we have developed MOSAIK, a fast and efficient reference-guided assembler, and EagleView, an information-rich visualization tool for a large genome assembly.
